Protonix iyo Nexium: Kala duwanaanshaha, isku ekaanshaha, iyo yaa kuu fiican adiga
Daroogada Vs. SaaxiibDulmarka daroogada & kala duwanaanshaha ugu weyn | Xaaladaha la daweeyay | Wax ku oolnimada | Caymiska caymiska iyo isbarbardhiga qiimaha | Dhibaatooyinka ay keento | Isdhexgalka daroogada | Digniinta | Su'aalaha
Protonix (pantoprazole) iyo Nexium (esomeprazole) waa laba daawo oo loo isticmaalo in lagu daaweeyo dhibaatooyinka habka dheef-shiidka, sida cudurka 'gastroesophageal reflux disease' (GERD). GERD waa xaalad daba-dheer oo soo baxda markii aysiidhka caloosha si joogto ah ugu soo noqdaan hunguriga caloosha. Tani waxay u horseedi kartaa astaamo sida laabjeex iyo dhibaatooyin aad u daran sida hunguriga hunguriga.
Protonix iyo Nexium labaduba waa qeyb ka mid ah fasalka daroogada ee loo yaqaan 'proton pump inhibitors' (PPIs). Waxay ku shaqeeyaan iyaga oo xannibaya bamka proton-ka ee caloosha, kuwaas oo mas'uul ka ah soo saarista aashitada. Saamayn ahaan, Protonix iyo Nexium waxay caawiyaan yareynta wax soo saarka guud ee aashitada caloosha.
Maxay yihiin farqiga u dhexeeya Protonix iyo Nexium?
Protonix, oo ay soo saarto shirkadda Pfizer, waa magaca sumadda loogu talagalay pantoprazole. Waa daawo dhakhtar qoro oo loo isticmaalo in lagu daaweeyo hunguriga hunguriga daran ee dadka waaweyn iyo carruurta da'doodu tahay 5 sano iyo wixii ka weyn. Waxaa loo heli karaa iyada oo ah 20 mg iyo 40 mg kiniin dib loo dhigo, iyo sidoo kale 40 mg dareere ah oo ganaax ah. Xaaladaha qaarkood, Protonix waxaa loo qaadan karaa sidii duritaanka xididka (IV).
Nexium waxaa soo saaray AstraZeneca waana magaca sumadda loogu talagalay esomeprazole. Waxaa loo heli karaa daawo ahaan ama warqad dhakhtar iibsi ah (OTC) oo loo isticmaalo in lagu daaweeyo GERD ee dadka waaweyn, carruurta, iyo dhallaanka jira 1 bil iyo wixii ka weyn. Si ka duwan Protonix, Nexium wuxuu u yimaadaa sidii 20 mg iyo 40 mg kaabsol-dib-u-sii-deyn ah. Nexium sidoo kale waxaa loo heli karaa sida 2.5 mg, 5 mg, 10 mg, 20 mg, iyo 40 mg oo ganaax ah.
| Farqiga ugu weyn ee u dhexeeya Protonix iyo Nexium | ||
|---|---|---|
| Protonix | Nexium | |
| Fasalka daroogada | Proton pump inhibitor (PPI) | Proton pump inhibitor (PPI) |
| Summad / astaan guud | Nooc nooc iyo nooc guud ah ayaa la heli karaa | Nooc nooc iyo nooc guud ah ayaa la heli karaa |
| Waa maxay magaca guud? | Pantoprazole | Esomeprazole |
| Waa noocee (yada) daroogadu soo gasho? | Kiniin dib-u-sii-daayay Baakadaha Granules ee ka joojinta dareeraha Budada xididka ee duritaanka | Kaabsol dib loo dhigay Baakadaha Granules ee ka joojinta dareeraha Budada xididka ee duritaanka |
| Waa maxay qiyaasta caadiga ah? | 40 mg hal mar maalintii | 20 ama 40 mg hal mar maalintii |
| Muddo intee le'eg ayaa daaweynta caadiga ah? | Ilaa 8 toddobaad | 4 ilaa 8 todobaad iyadoo kuxiran xaalada la daweynayo |
| Ayaa si caadi ah u isticmaala daawada? | Dadka waaweyn iyo carruurta da'doodu tahay 5 sano iyo wixii ka weyn | Dadka waaweyn, carruurta, iyo dhallaanka jira 1 bil iyo wixii ka weyn |
Xaaladaha ay daweeyaan Protonix iyo Nexium
Protonix iyo Nexium labaduba way daaweyn karaan GERD iyo xaaladaha la xiriira GERD, sida dib-u-celinta aashitada (laab-jeex). Labada daawoba sidoo kale waa FDA loo oggolaaday in lagu daaweeyo hunguriga hunguriga kacsan, ama caabuqa ku dhaca dahaarka hunguriga.
Nexium sidoo kale waa FDA loo ogolaaday in lagu daaweeyo infekshanka Helicobacter pylori (H. pylori). Cudurka noocan ah wuxuu soo baxaa marka bakteeriyada H. pylori ay ku dhacdo habka dheef-shiidka, taasoo u horseedi karta nabarro. Ka sokow boogaha uu keeno H. pylori, Nexium waxay ka hortagi kartaa halista boogaha la xiriira daawooyinka anti-inflammatory nonsteroidal (NSAIDs).
Labada Protonix iyo Nexium labadaba waxaa loo isticmaali karaa in lagu daaweeyo xaaladaha sirta ah, sida cudurka Zollinger-Ellison. Xaaladahaas waxaa lagu gartaa soo saarid saaid ah aashitada caloosha. Protonix iyo Nexium ayaa sidoo kale loo isticmaali karaa in lagu daaweeyo nabarrada 'peptic ulcers', oo ka kooban labada duculood iyo boogaha caloosha.
Protonix iyo Nexium waxaa lagula talinayaa oo keliya isticmaalka muddada-gaaban, ama illaa siddeed toddobaad inta badan kiisaska.
| Xaaladda | Protonix | Nexium |
| Cudurka 'refastrox refastroji' (GERD) | Haa | Haa |
| Cudurka hunguriga ee nugul | Haa | Haa |
| Xaaladaha sirta ah | Haa | Haa |
| Xanuunka H. pylori | Off-calaamadda | Haa |
| Khatarta yareynta nabarrada caloosha ee la xiriira NSAID | Off-calaamadda | Haa |
| Boogaha Duodenal | Off-calaamadda | Off-calaamadda |
| Boogaha caloosha | Off-calaamadda | Off-calaamadda |
| Laab xanuun | Off-calaamadda | Haa |
Protonix ama Nexium ma ka waxtar badan yihiin?
Tijaabooyin caafimaad ayaa muujiyay in pantoprazole iyo esomeprazole ay si isku mid ah waxtar u leeyihiin. Hal tijaabo caafimaad isbarbar dhiga waxtarka oo ah 40 mg ah pantoprazole ilaa 40 mg esomeprazole oo bukaannada qaba GERD. Qiyaastii 580 bukaan ayaa loo kala soocay si loo helo labada pantoprazole ama esomeprazole oo ka badan 4, 8, ama 12 toddobaad oo daaweyn ah. Gafida dhameystiran ee GERD waxaa lagu gaarey labada PPI heerar isku mid ah.
Tijaabinta tijaabada caafimaad ee laba-indhoole ah, waxtarka pantoprazole iyo esomeprazole ayaa la barbardhigay daaweynta GERD. Qiyaastii 200 bukaan ayaa loo kala soocay si ay u helaan 40 mg oo ah pantoprazole maalin kasta ama 40 mg esomeprazole maalin kasta. Labadaba PPI-yada ayaa la ogaaday inay yihiin siman wax ku ool ah leh badbaado iyo dulqaad la barbardhigi karo.
La tasho bixiye daryeel caafimaad xulashada daaweynta ugu fiican ee adiga kugu habboon. Bixiyahaaga daryeelka aasaasiga ah wuxuu kuu gudbin karaa dhakhtar ku takhasusay cilmiga caloosha si uu talo caafimaad oo dheeri ah uga helo.
Daboolida iyo qiimaha isbarbar dhiga Protonix iyo Nexium
Inta badan Medicare iyo qorshayaasha caymiska waxay dabooli doonaan nooca guud ee Protonix, pantoprazole. Lacag bixinta Medicare waxay u dhaxeysaa $ 0 ilaa $ 17 pantoprazole. Caymis la'aan, celceliska qiimaha lacagta ee Protonix waa $ 522. Si kastaba ha noqotee, iyada oo loo yaqaan 'Protonix coupon' oo ka socota SingleCare, qiimaha guud wuxuu ku saabsan yahay $ 11.
Qaar ka mid ah Medicare iyo qorshayaasha caymiska ayaa dabooli kara Nexium ama nooca guud, esomeprazole. Lacag bixinta Medicare ee esomeprazole waxay u dhaxeysaa $ 1 ilaa $ 41. Celceliska qiimaha tafaariiqda ee Nexium waa $ 478 iyadoo kuxiran tirada iyo awooda loo qoray. Kuuboonada 'SingleCare Nexium', sicirka celceliska ayaa laga dhimi karaa ugu yaraan $ 27.
| Protonix | Nexium | |
| Caadi ahaan caymiska ayaa daboolaya? | Haa, sida nooca guud | Haa, sida nooca guud |
| Caadi ahaan waxaa daboola Medicare Qaybta D? | Haa, sida nooca guud | Haa, sida nooca guud |
| Tirada | 30 kiniin (40 mg) | 30 kiniin (40 mg) |
| Bixinta lacagta caadiga ah ee 'Medicare' | $ 0– $ 17 | $ 1– $ 41 |
| Qiimaha SingleCare | $ 11 + | $ 27 + |
Waxyeelooyinka guud ee Protonix iyo Nexium
Saameynaha ugu caansan ee Protonix waa madax xanuun, shuban, lallabbo, calool xanuun, matag, gaas, wareer, iyo kalagoys xanuun.
Dhibaatooyinka guud ee Nexium waxaa ka mid ah madax xanuun, shuban, lallabbo, gaas, calool xanuun, calool istaag, iyo afka oo qallala.
Dhibaatooyinka halista ah ee PPIs badanaa waxay la xiriiraan isticmaalka muddada-dheer. Dhibaatooyinka halista ah waxaa ka mid noqon kara lafo jabka lafaha la xiriira, fitamiin B12 yaraanta, iyo heerarka magnesium ee hooseeya (hypomagnesemia).
| Protonix | Nexium | |||
| Waxyeellada | Ma khuseysaa? | Joogtaynta | Ma khuseysaa? | Joogtaynta |
| Madax xanuun | Haa | 12% | Haa | ≥1% |
| Shuban | Haa | 9% | Haa | ≥1% |
| Calool fadhiga | Haa | <2% | Haa | ≥1% |
| Af qalalan | Haa | <2% | Haa | ≥1% |
| Lallabbo | Haa | 7% | Haa | ≥1% |
| Calool xanuun | Haa | 6% | Haa | ≥1% |
| Matagid | Haa | 4% | Haa | <1% |
| Dawakhaad | Haa | 3% | Haa | <1% |
| Gaas | Haa | 4% | Haa | ≥1% |
| Xanuun wadajir ah | Haa | 3% | Maaha | - |
Joogtayntu kuma salaysna xogta laga soo qaaday tijaabo madax-ilaa-madax ah. Tani ma noqon karto liistada dhameystiran ee waxyeelooyinka xun ee dhici kara. Fadlan tixraac dhakhtarkaaga ama daryeel caafimaad si aad wax badan uga ogaato.
Xigasho: DailyMed ( Protonix ),, DailyMed ( Nexium )
Isdhexgalka daroogada ee Protonix iyo Nexium
Protonix iyo Nexium, sida PPI-yada kale, waxay la falgalaan dawooyin badan oo isku mid ah. PPI-yadaani waa in lala socdaa ama laga fogaadaa daawooyinka kale ee ku tiirsan aashitada caloosha ee nuugista. Daawooyinka ku tiirsan aashitada caloosha ee nuugista waxaa ka mid ah cusbada birta, erlotinib, ketoconazole, iyo mycophenolate mofetil.
Protonix iyo Nexium waxay sidoo kale la falgeli karaan daawooyinka antiretroviral, ama daawooyinka badanaa loo isticmaalo in lagu daaweeyo HIV. PPIs waxay kordhin karaan ama yareyn karaan heerarka dhiigga ee daawooyinka antiretroviral, taasoo horseedi karta halista sii kordheysa ee sunta ama hoos u dhaca waxtarka daawooyinka antiretroviral.
Isticmaalka Protonix ama Nexium oo leh warfarin waxay kordhin kartaa halista dhiig bax.
Nexium waa in lala socdaa ama laga fogaadaa diazepam maxaa yeelay waxay kordhin kartaa heerarka dhiigga ee diazepam waxayna horseedi kartaa halista sii kordheysa ee saameynta xun. Isticmaalka Nexium iyo clopidogrel waa in sidoo kale laga fogaadaa. Nexium wuxuu yareyn karaa sida ugu wanaagsan ee clopidogrel ugu shaqeeyo jirka, taasoo kordhin karta halista xinjirowga dhiigga.
| Daroogada | Nooca daroogada | Protonix | Nexium |
| Atazanavir Rilpivirine Nelfinavir Saquinavir | Antiretroviral | Haa | Haa |
| Ketoconazole | Antifungal | Haa | Haa |
| Salfateet Ferrous Gluconate fuula Fumarate fuuxan | Milix birta ah | Haa | Haa |
| Mycophenolate mofetil Methotrexate | Immunosuppressant | Haa | Haa |
| Erlotinib | Dawaynta kimikalka | Haa | Haa |
| Digoxin | Glycoside wadnaha | Haa | Haa |
| Warfarin | Anticoagulant | Haa | Haa |
| Diazepam | Benzodiazepine | Maaha | Haa |
| Clopidogrel | Antiplatelet | Maaha | Haa |
Kala tasho xirfadle daryeel caafimaad isdhexgalka kale ee dawooyinka ee suurtogalka ah
Digniinta Protonix iyo Nexium
Adeegsiga muddada-dheer ee PPIs wuxuu u horseedi karaa halista sii kordheysa ee jabka lafaha, gaar ahaan dadka horeyba looga helay cudurka lafo-beelka. Cufnaanta macdanta lafaha ayaa laga yaabaa inay u baahan tahay in lala socdo inta lagu jiro daaweynta muddada dheer ee PPIs.
Bukaanjiifka qaar waxay soo mareen xanuun daran oo loo yaqaan 'tubulointerstitial nephritis' (TIN) inta ay qaadanayaan Protonix ama Nexium. Cudurka neerfaha waa caabuq ku dhaca kelyaha, taasoo u horseedi karta hoos u dhaca shaqada kilyaha.
Isticmaalka PPIs wuxuu ku xirnaan karaa halista sii kordheysa ee shuban-biyoodka la xiriira Clostridium. Kuwa la kulma shuban joogto ah waxay u baahan karaan in lala socdo, gaar ahaan goobta isbitaalka.
Qaadashada Protonix ama Nexium waxay kordhin kartaa halista heerarka dhiigga ee hooseeya ee magnesium (hypomagnesemia) ama fitamiin B12 (fitamiin B12 yaraanta). Waxaa jira halista sii kordheysa ee hypomagnesemia iyo fitamiin B12 yaraanta kuwa ku jira daaweynta muddada dheer ee PPIs.
La tasho bixiyahaaga daryeelka caafimaadka wixii ah digniino iyo taxaddarro kale oo suuragal ah ka hor intaadan qaadin PPI.
Su'aalaha badanaa la isweydiiyo ee ku saabsan Protonix iyo Nexium
Waa maxay Protonix?
Protonix waa daawada kaliya ee PPI ee loogu talagalay in lagu daaweeyo esophagitis-ka nabaad-guurka ee la xiriira GERD. Protonix waxaa loo heli karaa kiniin daahitaan ah iyo hakin dareere ah. Magaca guud ee Protonix waa pantoprazole.
Waa maxay Nexium?
Nexium waa daawo PPI ah oo loo adeegsado in lagu daaweeyo qulqulka aashitada iyo laabjeexa, iyo sidoo kale hunguriga hunguriga keena ee la xiriira GERD. Waxaa lagu heli karaa warqad rijeeto ah ama miiska lagu iibsado. Nexium ugu horreyntii wuxuu yimaadaa kaabsal-dib-u-sii-deyn ama hakin dareere ah. Magaca guud ee Nexium waa esomeprazole.
Protonix iyo Nexium ma isku mid baa?
Protonix iyo Nexium waa laba dawo oo PPI ah oo daaweyn kara GERD, xaaladaha xasaasiga ah, iyo boogaha caloosha. Si kastaba ha noqotee, waxay ka kooban yihiin maaddooyin firfircoon oo kala duwan waxayna ku yimaadaan qaabab kala duwan. Protonix wuxuu ka kooban yahay pantoprazole iyo Nexium waxaa ku jira esomeprazole. Protonix wuxuu daaweyn karaa GERD dadka waaweyn iyo carruurta da'doodu tahay 5 sano iyo wixii ka weyn halka Nexium uu daaweyn karo GERD dadka waaweyn, carruurta, iyo dhallaanka jira hal bil iyo ka weyn.
Ma Protonix ama Nexium ayaa ka fiican?
Protonix iyo Nexium waxay la mid yihiin wax ku oolnimada. PPI-da ugu habboon ayaa lagu go'aamin doonaa iyadoo lagu saleynayo da'da, xaaladda caafimaad, kharashka, caymiska, iyo daawooyinka kale ee la qaato.
Ma isticmaali karaa Protonix ama Nexium inta aan uurka leeyahay?
Protonix ama Nexium ayaa badbaado leh in la qaato inta aad uurka leedahay. Si kastaba ha noqotee, waa in la adeegsadaa oo keliya haddii faa'iidooyinka ay ka culus yihiin halista. Xilligan, ma jiraan daraasado ku filan oo muujinaya in Protonix ama Nexium ay gebi ahaanba ammaan yihiin in la isticmaalo xilliga uurka. La tasho bixiye daryeel caafimaad talo caafimaad oo ku saabsan daaweynta ugu fiican ee GERD inta aad uurka leedahay.
Ma ku isticmaali karaa Protonix ama Nexium aalkolo?
In kasta oo aalkolada aan lagu aqoon inay la falgalaan Protonix ama Nexium, haddana waxay ka sii dari kartaa astaamaha aashitada iyo calaamadaha laab-jeexa ee dadka qaarkood. Isticmaalka khamrigu wuxuu badbaado u noqon karaa dhexdhexaad marka la qaadanayo Protonix ama Nexium, laakiin guud ahaan laguma talin.
Muxuu yahay waxqabadka ugu waxtarka badan ee proton pump inhibitor?
PPI-ta ugu waxtarka badan waxay ku xirnaan doontaa xaaladda la daweynayo, qiyaasta PPI, iyo daawooyinka kale ee laga yaabo inuu qofku qaato. Kharashka PPI sidoo kale waa in la tixgeliyaa marka la go'aaminayo ikhtiyaarka ugu wax ku oolka badan.
Maxaan qaadan karaa halkii aan ka ahaan lahaa Nexium?
Nexium (esomeprazole) waa proton pump inhibitor ka. Kuwa kale ee ka hortaga bamka proton-ka waxaa ka mid ah Prilosec (omeprazole), Prevacid (lansoprazole), Aciphex (rabeprazole), iyo Protonix (pantoprazole). Haddii astaamaha GERD aysan ku soo fiicnaan PPI, bixiye daryeel caafimaad ayaa kugula talin kara daawada H2 xannibaadaha. Tusaalooyinka H2 blockers waxaa ka mid ah Pepcid (famotidine), Zantac (ranitidine), iyo Tagamet (cimetidine).
Nexium ma ka sii dari kartaa reflux-ka?
Nexium waxaa loo isticmaalaa in lagu daaweeyo reflux acid. Joojinta daaweynta Nexium waqti kahoreysa sidii ay ugula taliyeen bixiye daryeel caafimaad waxay u horseedi kartaa soo noqoshada astaamaha reflux. Nexium waxaa laga yaabaa inaysan u wada shaqeyn dadka oo dhan. Haddii astaamuhu aysan ku fiicnayn Nexium, xulashooyinka kale ee daaweynta ayaa lagu talin karaa.
