Waa maxay NSAIDs?

Macluumaadka Daroogada

Liiska NSAID | Waa maxay NSAIDs? | Sida ay u shaqeeyaan | Isticmaala | Ayaa qaadan kara NSAIDs? | Amniga | Dhibaatooyinka ay keento | Kharashaadka

Haddii aad waligaa la kulantay nooc kasta oo xanuun ama caabuq ah, waxaad u maleyneysaa inaad qaadatay daawo NSAID ah oo loogu talagalay gargaarka xanuunka muddada-gaaban (saameynta xanuunka). NSAIDs waa dawooyinka anti-bararka ee nonsteroidal. Waxaa loo adeegsadaa carruurta iyo dadka waaweyn, waxay caawiyaan xanuunno badan oo kala duwan oo keeni kara xanuun ama caabuq. Akhriso si aad waxbadan uga ogaato waxyaabaha ku saabsan NSAIDs - oo ay kujiraan magacyada caanka ah ee caanka ah, isticmaalkiisa, iyo macluumaadka badbaadada Jaantuskani wuxuu liis garayaa NSAID-yada ugu badan iyo macluumaadka qiimaha.

Liiska NSAIDs
Magaca sumadda (magaca guud)	Celceliska qiimaha lacagta caddaanka ah ee guud	Qiimaha SingleCare	Wax dheeri ah baro
Advil, Motrin (ibuprofen) *	$ 50 halkii 30, kaniiniyada 800 mg	Soo qaado kuuboonada ibuprofen	Faahfaahinta Ibuprofen
Aleve, Anaprox, Anaprox DS, Naprosyn, Naprelan (naproxen) *	$ 53 30, 30 mg kiniin ah	Soo qaado rasiidhada naproxen	Faahfaahinta Naproxen
Celebrex (celecoxib)	$ 360 30, 200 mg kaabsal	Hel kuubbo Celebrex	Faahfaahinta Celebrex
Rugta caafimaadka (sulindac)	$ 65 oo loogu talagalay 60, 200 mg kiniin ah	Hel Kuuboon Clinoril	Faahfaahinta rugta caafimaadka
Feldene (piroxicam)	$ 183 30, 10 mg kaabsal	Hel kuubbo Feldene ah	Feldene faahfaahin
Indocin (indomethacin)	$ 32 30, 50 mg kaabsal	Hel kuubbo Indocin	Faahfaahinta Indocin
Lodine (etodolac)	$ 70 oo loogu talagalay 60, 400 mg kiniin ah	Hel kuubbo Lodine	Faahfaahinta Lodine
Mobic (meloxicam)	$ 210 30, 15 kiniin oo mg ah	Hel kuubbo Mobic ah	Faahfaahinta Mobic
Orudis (ketoprofen)	$ 52 $ 30, kiniiniyada mg 75	Hel kuubbo Orudis ah	Faahfaahinta Orudis
Relafen (nabumetone)	$ 80 $ 60, kiniiniyada 500 mg	Hel kuubbo Relafen ah	Faahfaahinta Relafen
Toradol (ketorolac)	$ 127 oo loogu talagalay 20, 10 mg kiniin ah	Hel kuub Toradol ah	Faahfaahinta Toradol
Voltaren, Voltaren-XR (diclofenac sodium, afka)	$ 25 30, 50 kiniin oo mg ah	Hel kuubbo Voltaren (afka ah)	Faahfaahinta Voltaren (afka)
Jel Voltaren (diclofenac, mowduuc) *	$ 82 oo ah tuubo 100-garaam ah	Hel kuubbo Voltaren (mawduuc leh)	Faahfaahinta Voltaren (mowduuc)

* Waxaa lagu heli karaa rijeetada iyo daawooyinka OTC

NSAID-yada kale waxaa ka mid ah:

• Ansaid (flurbiprofen)
• Arthrotec (diclofenac / misoprostol)
• Cataflam (diclofenac potassium)
• Daypro (oxaprozin)
• Disalcid (salsalate)
• Dolobid (kala duwanaansho)
• Flector (diclofenac mowduuc)
• Meclomen (meclofenamate)
• Nalfon (fenoprofen)
• Pennsaid (diclofenac mowduuc)
• Ponstel (mefenamic acid)
• Solaraze (diclofenac mowduuc)
• Tolectin (tolmetin)
• Sipsor (diclofenac potassium)

Waa maxay NSAIDs?

Daawooyinka nonsteroidal anti-bararka waa dawooyin caan ah oo daaweeya xanuunka iyo caabuqa xaaladaha kala duwan sida arthritis, dhabar xanuun, iyo madax xanuun. Waxay kaloo kaa caawin karaan yareynta qandhada. In kasta oo ay jiraan dawooyin badan oo NSAIDs ah, qaar baa laga heli karaa miiska laga iibsado (OTC) sida aspirin iyo ibuprofen.

Ogsoonow in Tylenol, oo ay ku jirto acetaminophen, badanaa lagu xuso daawooyinkan, laakiin Tylenol maaha NSAID.

Sidee u shaqeeyaan NSAIDs?

NSAIDs waxay ku shaqeeyaan xayiraadda enzymes-ka loo yaqaan COX-1 iyo COX-2. COX waxay u taagan tahay cyclooxygenase. Enzymes-kan ayaa sameeya prostaglandins, oo keena xanuun iyo barar. Adoo xannibaya enzymes-kan, jirkaaga wuxuu soo saaraa wax ka yar qanjirka 'prostaglandins', taasoo keenta xanuun iyo caabuq yar. ( Celebrex waa NSAID oo ah kahortaga COX-2. Adoo xiraya kaliya COX-2, waxaa jiri kara waxyeelo yar oo caloosha ah.)

NSAIDs waa kuwo waxtar leh oo badanaaba xakameyn kara xanuunka, kana ilaaliya bukaanka inay qaataan daawooyin adag sida opioids, oo leh waxyeelo aad u daran iyo awood sare oo xadgudub iyo ku tiirsanaan.

Markaad isku aragto xanuun fudud ama dhexdhexaad ah ama caabuq u baahan NSAID, tallaabooyin kale ayaa sidoo kale kaa caawin kara. Weydii bixiyahaaga daryeelka caafimaadka hagitaan caafimaad oo ku saabsan xeeladaha kale ee maaraynta xanuunka sida barafka ama kuleylka, daaweynta jirka, iyo nasashada.

Maxaa loo adeegsadaa NSAIDs?

NSAIDs waxay waxtar u leeyihiin xaalado kala duwan oo keena xanuun fudud iyo dhexdhexaad iyo caabuq, sida:

• Dhabar xanuun
• Murqo xanuun
• Dhaawacyada / murgacashada isboortiga
• Madax xanuun
• Qandho
• Xanuun ilkaha
• Rheumatoid arthritis
• Cudurka 'rheumatoid arthritis' ee carruurta
• Cudurka Osteoarthritis
• Tendonitis
• Cudurka 'Ankylosing spondylitis'
• Dhadhaminta rootiga
• Bursitis
• Xanuunka caadada

Maaddaama tilmaamaha gaarka ahi ay ku kala duwan yihiin alaabooyinka, weydii xirfadlahaaga daryeelka caafimaadka talo caafimaad oo ku saabsan xannuun joojiye ugu habboon xaaladdaada.

Ayaa qaadan kara NSAIDs?

Laakiin

Ragga qaangaarka ah badankood waxay qaadan karaan NSAIDs illaa ay ka hoos galaan mid ka mid ah kooxaha xaddidan ee hoose.

Haweenka

Dumarka qaangaarka ah badankood waxay qaadan karaan NSAIDs illaa ay ku dhacaan qayb xaddidan oo hoos ku taxan. Haweenka uurka lihi waa inaysan qaadanin NSAIDs saddexda bilood ee saddexaad ee uurka maxaa yeelay waxay u keeni karaan dhaawac halis ah ilmaha aan dhalan.

Caruurta

Qaar ka mid ah NSAIDs aan dhakhtar qorin, sida Advil iyo Motrin, ayaa loo heli karaa carruurta ka weyn 6 bilood, laakiin hubi inaad ka hubiso qiyaasta ku habboon dhakhtarka carruurtaada ama farmashiistahaaga. Qiyaasta daawadu way kala duwan tahay sameynta, da'da, iyo culeyska. Qaababka qaarkood ayaa aad isugu uruursan, taasoo la micno ah in ilmuhu heli doono dawo dheeraad ah oo aad u tiro yar. Taasi waa sababta ay muhiim u tahay in la akhriyo Calaamadaha Xaqiiqda Daroogada alaabta gaarka ah, iyo hubi laba jeer daryeel bixiyahaaga haddii aadan hubin. Sidoo kale, isticmaal koob qaadasho ama siliingaha afka si aad u cabirto qiyaasta ku habboon. Ha isticmaalin malqacadaha lagu cabiro jikada, maxaa yeelay kuwani waxay ku qaldan yihiin qiyaasta daawada.

In kasta oo Aleve laga heli karo OTC, looma isticmaali karo carruurta da'doodu ka yar tahay 12 sano.

Daawooyinka NSAIDs lagu qoro waxay ku kala duwan yihiin da'da iyo tilmaamaha, markaa weydii daryeel caafimaad bixiyaha haddii aad su'aalo qabtid.

Waayeelka

NSAIDs ayaa saaran Liiska Beerka daawooyinka laga yaabo inayna ku habboonayn dadka waaweyn. Waxaa jira qatar sare oo ah in dhiig caloosha ama nabarro ku dhacaan dadka ka weyn 75 sano. Qaadashada kahortaga borotokoolka sida Prilosec waxay yareyn kartaa halista waxyeellooyinka caloosha, laakiin kama baabi'inayso halista. Dadka waayeelka ah waa inay sidoo kale ka fogaadaan NSAIDs sababtoo ah halista sii kordheysa ee wadnaha oo istaaga, dareeraha haynta, iyo dhaawaca kelyaha.

NSAIDs ma nabad qabaan?

Xayiraadaha NSAID

Ha u qaadan NSAIDS haddii aad:

• Aad xasaasiyad ku leedahay wax kasta oo NSAID ah.
• Hayso taariikh neef ama xasaasiyad xasaasiyad asbiriin ama NSAIDs kale.
• Waxay ku dhowdahay in lagu sameeyo (ama hadda uun la qalay) qalliinka CABG.
• Waxay ku jiraan seddex biloodlaha seddexaad ee uurka. Haddii aad ku jirto bilaha koowaad ama labaad, ama haddii aad naas nuujiso, weydii xirfadlahaaga daryeelka caafimaadka talo caafimaad.

Digniinta NSAID

Dhammaan NSAIDs waxay leeyihiin a digniinta sanduuqa madow . Digniinta sanduuqa madow waa digniinta ugu halista badan sida ay u baahan tahay FDA (Maamulka Cuntada iyo Dawooyinka ee Mareykanka). Digniintan waxaa ka mid ah:

• Khatarta wadnaha iyo xididdada dhiigga : NSAIDs waxay sababaan halista sii kordheysa ee xinjirowga dhiigga, wadnaha, iyo istaroogga, oo noqon kara mid dilaa ah. Khatartu waxay jirtaa bilowga daaweynta, halistuna waxay sii kordheysaa muddada daawada la isticmaalayo. NSAIDs looma isticmaali karo ka hor ama ka dib qalliinka halbowlaha wadnaha (CABG).
• Khatarta caloosha (GI) : NSAIDs waxay kordhiyaan halista dhiig-baxa, cuncunka maqaarka / boogaha caloosha, iyo daloolka caloosha iyo mindhicirada. Tani waxay noqon kartaa mid dilaa ah. Dhibaatooyinkan GI-ga ah waxay dhici karaan wakhti kasta inta lagu jiro isticmaalka NSAID iyo digniin la'aan. Cunsurrada halista waxaa ka mid ah dadka waaweyn ee waaweyn iyo bukaanada leh taariikh GI oo dhiig baxa iyo / ama nabarro.

Digniinta kale waxaa ka mid ah:

• Marar dhif ah, dhibaatooyinka beerka ayaa dhici kara. Waxay noqon karaan kuwo halis ah ama dilaa ah. U sheeg dhakhtarkaaga haddii aad leedahay calaamado sida lallabbo, daal, cuncun, calool xanuun hoose, cagaarshow, ama shuban.
• Cadaadiska dhiigga waa in lala socdaa muddada daaweynta.
• Sababtoo ah NSAIDs waxay kordhiyaan halista wadnaha oo istaaga iyo barar, waa in guud ahaan laga fogaadaa dadka qaba wadno xanuun daran.
• Isticmaalka muddada-dheer wuxuu sababi karaa dhibaatooyin kelyaha waana in guud ahaan laga fogaadaa bukaannada qaba cudurrada kalyaha ee sareeya.
• Hel gargaar caafimaad oo deg-deg ah haddii calaamado fal-celinta xasaasiyadeed ay dhacaan, sida cuncun, neefsashada oo ku adkaata, ama bishimaha bushimaha, wejiga, ama carrabka.
• NSAIDs waxay sababi karaan falcelin maqaarka oo daran sida Stevens-Johnson Syndrome ama sunta epidermal necrolysis (TEN). Kuwaani waxay noqon karaan kuwo dilaa ah waxayna dhacaan digniin la’aan. Jooji qaadashada NSAID oo raadso gargaar deg-deg ah haddii aad maqaarka ku fal-celiso. Ha u isticmaalin NSAIDs haddii aad hore u yeelatay falcelin maqaar oo ku saabsan NSAID.
• NSAIDs waxay sababi karaan dhiig yaraan. Khatarta dhiigbaxa NSAIDs waxay sii kordheysaa isticmaalka daawooyinka qaarkood sida corticosteroids, daawada xinjirowga lidka ku ah (sida warfarin), antiplatelets, ama SSRI ama SNRI antidepressants.
• Haddii aad qaadato NSAID muddo dheer, weydii dhakhtarkaaga wixii ku saabsan baadhitaannada shaybaadhka. Sababtoo ah dhammaan halista la xiriirta NSAIDs, waxaa ugu wanaagsan in la qaato qaddarka ugu hooseeya ee suurtogalka ah, muddada ugu yar. Haddii aad isticmaaleyso OTC NSAID, weydii dhakhtarkaaga kahor intaadan isticmaalin in ka badan 10 maalmood. Xanuunka daba-dheeraada wuxuu u baahan karaa daawo ka duwan.

U sheeg daryeel caafimaad bixiyahaaga dhammaan daawooyinka aad qaadato, oo ay ku jiraan rijeetooyinka, OTC, iyo fiitamiinnada, si isaga ama iyadu ay u hubiyaan in NSAID ay ammaan ku tahay daawooyinka kale ee aad qaadato. NSAIDs waxay la falgalaan daawooyinka qaarkood sida SSRI ama SNRI antidepressants, daawooyinka xinjirowga lidka ku ah, lithium, ACE inhibitors, ARBs, iyo diuretics.

NSAIDs looma isticmaali karo saddexda bilood ee uurka, maxaa yeelay waxay u geysan karaan waxyeelo daran ilmaha aan dhalan.

NSAID wuu xasuustaa

• Xusuusinta duritaanka Ketorolac (Maarso 2020)
• Xusuusinta duritaanka Ketorolac (Abriil 2019)
• Dib u soo celinta Ibuprofen ee afka ah (Janaayo 2019)
• Xusuusashada ibuprofen dhallaanka (Diseembar 2018)

Vioxx iyo Bextra labaduba waxay ahaayeen COX-2 xakameeyayaal oo laga saaray suuqa sababo la xiriira dhibaatooyin wadnaha oo daran.

Ma qaadan kartaa NSAIDs inta aad uurka leedahay ama aad naas nuujineyso?

Ha u qaadan NSAIDs saddexda bilood ee saddexaad ee uurka. Daawooyinkani waxay u horseedi karaan dhaawac nafta halis gelinaya ilmaha aan dhalan. Haddii aad ku jirto seddexda bilood ee ugu horreeya ama kan labaad, ama haddii aad mar hore qaadatid NSAID oo aad ogaatid inaad uur leedahay, la tasho daryeel caafimaad bixiyahaaga si aad u hesho hagitaan.

Haddii aad naas nuujinayso, kala tasho xirfadlahaaga daryeelka caafimaadka talo caafimaad.

NSAIDs ma yihiin walxo la koontaroolo?

Maya, NSAIDs ma aha walxo la kontoroolo.

Waxyeelooyinka guud ee NSAIDs

NSAID xanuun joojiyeyaasha badanaa si fiican ayaa loo dulqaataa laakiin waxay sababi karaan waxyeelo badan, qaarkoodna waxay noqon karaan kuwo halis ah. Saameynaha ugu caansan waxaa ka mid ah GI (gastrointestinal) waxyeelo sida calool xanuun, calool istaag, shuban, gaas, laab xanuun, lallabbo, iyo matag. Dawakhaad sidoo kale waa waxyeellooyin caadi ah.

Kale, waxyeelo daran ayaa dhici karta. Kuwaas waxaa ka mid noqon kara:

• Dhibaatooyinka wadnaha sida wadne qabad, istaroog, dhiig kar (dhiig kar), ama wadne istaag
• Dhibaatooyinka kilyaha ama beerka
• Dhibaatooyinka GI sida dhiigbaxa iyo boogaha caloosha iyo xiidmaha
• Unugyada dhiigga cas ee hooseeya
• Maqaarka nafta halis geliya ama falcelinta xasaasiyadda
• Neefta waxay ku dhacdaa bukaanka neefta

Haddii aad isku aragto mid ka mid ah astaamahan, hel daaweyn caafimaad oo degdeg ah:

• Neefsashada oo ku adkaata ama neefsashada oo kugu adkaata
• Laab xanuun
• Tabar-yarida hal dhinac oo jirka ah
• Hadal dabacsan
• Barar wejiga ama cunaha ah

Jooji qaadashada NSAID-gaaga isla markaana wac dhakhtarkaaga haddii aad leedahay mid ka mid ah astaamahan:

• Lallabbo
• Dareemid daal aan caadi ahayn ama daciifnimo
• Cuncun, finan maqaarka ah, ama finan leh xummad
• Jaale maqaarka ama indhaha oo cad
• Calaamadaha Flulike
• Matag dhiig
• Saxaro madow, daah, ama saxaro dhiig leh
• Barar gacmaha / lugaha / gacmaha / cagaha

Tani ma aha liistada dhammaystiran ee waxyeellooyinka soo raaca. Kala tasho daryeel caafimaad bixiyahaaga liistada buuxda ee waxyeelooyinka.

Waa imisa kharashka NSAIDs?

NSAIDs waa xulasho caan ah oo ka dhexeysa bixiyeyaasha daryeelka caafimaadka maxaa yeelay kaliya ma ahan kuwo wax ku ool ah laakiin jaban sidoo kale. Waxaad ku iibsan kartaa OTC NSAIDs $ 5 iyo wixii ka sareeya, iyadoo kuxiran cabirka baakadka iyo qaabeynta. NSAID-yada rijeetada-daawada sidoo kale waa dhaqaale, iyadoo qiimaha kala duwan yihiin wax soo saarka, xoog, iyo tirada. Waxaad had iyo jeer isticmaali kartaa bilaash Kaarka SingleCare si aad lacag ugu kaydiso warqadda daawada NSAID iyo xitaa foomamka OTC oo leh warqad dhakhtar oo sax ah.