Pravastatin iyo Lipitor: Kala duwanaanshaha, isku ekaanshaha, iyo yaa kuu fiican adiga
Daroogada Vs. SaaxiibDulmarka daroogada & kala duwanaanshaha ugu weyn | Xaaladaha la daweeyay | Wax ku oolnimada | Caymiska caymiska iyo isbarbardhiga qiimaha | Dhibaatooyinka ay keento | Isdhexgalka daroogada | Digniinta | Su'aalaha
Pravastatin iyo Lipitor (atorvastatin) waa daawooyin dhakhtar qoro oo loo isticmaalo in lagu daaweeyo kolestaroolka sare. Heerarka kolestaroolka ee ka sarreeya inta caadiga ah waxay kordhin karaan halista cudurrada wadnaha, cudurrada xididdada dhiigga, wadne istaagga, iyo istaroog. Kalastaroolka ayaa ugu horreyn lagu soo saaraa beerka iyada oo loo marayo HMG-CoA reductase enzyme.
Pravastatin iyo atorvastatin waa daawooyin lagu tilmaamay inay yihiin kuwa kahortaga HMG-CoA reductase. Sidoo kale loo yaqaan dawooyinka statin, pravastatin iyo atorvastatin inhibit, ama block, HMG-CoA reductase enzyme, taas oo horseedaysa hoos u dhaca soosaarka kolestaroolka ee beerka. Isticmaalka statins wuxuu kaloo kordhiyaa qadarka LDL (low-density lipoprotein) receptors ee beerka, kaas oo ka caawiya heerarka hoose ee LDL, ama nooca xun ee kolestaroolka, dhiiga.
Labada pravastatin iyo atorvastatin labadaba waxay u shaqeeyaan siyaabo isku mid ah, laakiin waxay leeyihiin kala duwanaansho ay tahay in laga feejignaado.
Maxay yihiin farqiga u dhexeeya pravastatin iyo Lipitor?
Pravastatin waa magaca guud ee Pravachol. Si ka duwan daroogooyinka kale ee statin, pravastatin si ballaaran looma dheef-shiidin, ama laga baaraandegin, by CYP3A4 enzymes beerka. Taabadalkeed, pravastatin waa caloosha ku burburay .
Kiniiniyada guud ee loo yaqaan 'Pravastatin' ayaa lagu heli karaa xoogagga 10 mg, 20 mg, 40 mg, iyo 80 mg. Pravastatin waxaa badanaa loo qoraa in la qaato hal mar maalintii fiidkii. Waxaa la muujiyay in pravastatin uu waxtar badan leeyahay marka la qaato fiidkii halkii aroortii.
Liifayaashu waa dawooyin magac ku caan ah waxaana lagu heli karaa nooc guud oo loo yaqaan 'atorvastatin'. Si ka duwan pravastatin, atorvastatin waxaa si xoog leh u shaqeynaya CYP3A4 enzyme ee beerka. Sidaa darteed, atorvastatin waxaa suuragal ah inuu la falgalo daawooyin ka badan kan pravastatin.
Liifle ayaa lagu heli karaa kaniiniyada afka laga qaato oo leh awooda 10 mg, 20 mg, 40 mg, iyo 80 mg. Qasaarahu waa la qaadan karaa subaxdii ama fiidkii, waxaana badanaa la qaataa hal mar maalintii.
| Farqiga ugu weyn ee u dhexeeya pravastatin iyo Lipitor | ||
|---|---|---|
| Pravastatin | Khasaaraha | |
| Fasalka daroogada | HMG-CoA reductase joojiye | HMG-CoA reductase joojiye |
| Summad / astaan guud | Nooc nooc iyo nooc guud ah ayaa la heli karaa | Nooc nooc iyo nooc guud ah ayaa la heli karaa |
| Waa maxay magaca guud? Waa maxay magaca sumaddu? | Magaca sumadda: Pravachol Magaca guud: Pravastatin | Magaca sumadda: Libaaxle Magaca guud: Atorvastatin |
| Waa noocee (yada) daroogadu soo gasho? | Kiniin afka ah | Kiniin afka ah |
| Waa maxay qiyaasta caadiga ah? | 10 illaa 80 mg hal mar maalintii | 10 illaa 80 mg hal mar maalintii |
| Muddo intee le'eg ayaa daaweynta caadiga ah? | Muddo-dheer | Muddo-dheer |
| Ayaa si caadi ah u isticmaala daawada? | Dadka waaweyn; carruurta iyo dhalinyarada da'doodu tahay 8 ilaa 18 sano jir | Dadka waaweyn; carruurta iyo dhalinyarada da'doodu tahay 10 ilaa 17 sano |
Xaaladaha lagu daaweeyo pravastatin iyo Lipitor
Pravastatin iyo atorvastatin waxay kaa caawin karaan yareynta halista wadno qabadka iyo faalig dadka qaba cudurka wadnaha. Labada daawoba waxay kaloo kaa caawin karaan yareynta halista dhimashada cudurada wadnaha . Waxyaabaha halista u ah cudurka wadnaha waxaa ka mid ah dhiig karka, sigaar cabista, iyo heerarka kalastarolka oo sareeya.
Labada pravastatin iyo atorvastatin labaduba waa FDA loo oggolaaday in la yareeyo wadarta guud ee kolestaroolka iyo heerarka LDL (oo sidoo kale loo yaqaan 'hyperlipidemia' ama 'hypercholesterolemia'). Daawooyinka Statin ayaa sidoo kale kaa caawin kara daaweynta heerarka sare ee triglycerides , oo ah nooc kale oo dufan ama dufan ku jira jirka. Qof leh heerar sare ee triglycerides wuxuu leeyahay hypertriglyceridemia.
Pravastatin iyo Lipitor sidoo kale waxay kordhin karaan heerarka HDL ee dhiiga. Kolestaroolka HDL waa waxa loo yaqaan kolestaroolka wanaagsan ee dhiigga ku jira.
| Xaaladda | Pravastatin | Khasaaraha |
| Hyperlipidemia | Haa | Haa |
| Hypercholesterolemia | Haa | Haa |
| Hypertriglyceridemia | Haa | Haa |
Miyuu pravastatin ama Lipitor waxtar badan yahay?
Labada pravastatin iyo atorvastatin labaduba waa daawooyin wax ku ool ah oo lagu daaweeyo kolestaroolka dhiigga sareeya. Daawada waxtarka badan waxay kuxirantahay xaaladaada guud, darnaanta xaaladaada, daawooyinka kale ee laga yaabo inaad qaadato, iyo qodobo kale.
Mid daraasad isbarbardhig ah waxay ogaatay in uusan jirin farqi weyn oo u dhexeeya pravastatin, simvastatin, iyo atorvastatin si looga hortago dhacdooyinka wadnaha iyo xididdada. Si kale haddii loo dhigo, dawooyinkan statin waxay si isku mid ah waxtar ugu yeesheen yaraynta weerarada wadnaha iyo wadnaha iyo xididdada dhiigga.
KU dib u eegis nidaamsan oo isku xirtay in ka badan 90 tijaabooyin caafimaad ah marka la barbardhigo daawooyinka statin sida fluvastatin, atorvastatin, pravastatin, simvastatin, iyo rosuvastatin. Dib-u-eegista ayaa lagu soo gabagabeeyay in atorvastatin, fluvastatin, iyo simvastatin ay leeyihiin suurtogalnimada ugu sarreysa ee noqoshada daaweynta ugu fiican ee looga hortago dhacdooyinka wadnaha.
La tasho bixiye daryeel caafimaad si aad u go'aamiso dawada ugu wanaagsan ee dawada 'statin' adiga kugu habboon. Kadib sameynta baaritaanka dhiigga iyo qiimeynta xaaladaada guud, adeeg bixiye ayaa awoodi doona inuu go'aansado in pravastatin ama atorvastatin uu yahay daawo adiga waxtar kuu leh. Waxay sidoo kale qori karaan daroogo statin ka duwan sida Zocor (simvastatin) ama Crestor (rosuvastatin).
Caymiska iyo isbarbar dhiga qiimaha ee pravastatin iyo Lipitor
Pravastatin waa daawo guud oo badanaa laga helo Medicare iyo qorshooyinka caymiska. Celceliska qiimaha lacagta caddaanka ah ee pravastatin waa qiyaastii $ 129.99 oo ah 30-maalmood oo alaab ah. Kaarka keydka ee 'SingleCare' ayaa laga yaabaa inuu awoodo inuu hoos u dhigo qiimaha daawada pravastatin uu kayar yahay $ 15.
Lipitor waa daawo magac ku caan ah oo sidoo kale lagu heli karo nooc jaban, nooc guud ah. Nooca guud ee Lipitor, atorvastatin, ayaa sida caadiga ah lagu daboolaa inta badan Medicare iyo qorshooyinka caymiska. Magaca Calaamadee Qaan-qaadaha waxaa dabooli kara qorshooyinka caymiska oo leh lacag-bixin sare. Qiimaha lacagta caddaanka ah ee Lipitor waa qiyaastii $ 249.99. Kuuboonada SingleCare waxay hoos u dhigi karaan qiimaha ilaa $ 15 farmasiyada kaqeyb galaya.
| Pravastatin | Khasaaraha | |
| Caadi ahaan caymiska ayaa daboolaya? | Haa | Haa |
| Caadi ahaan waxaa daboola Medicare Qaybta D? | Haa | Haa |
| Tirada | 30 kiniin (40 mg) | 30 kiniin (40 mg) |
| Bixinta lacagta caadiga ah ee 'Medicare' | $ 0– $ 20 | $ 0– $ 16 |
| Qiimaha SingleCare | $ 12 + | $ 15 + |
Dhibaatooyinka guud ee wadaagga ah ee pravastatin iyo Lipitor
Dhibaatooyinka ugu badan ee daawada pravastatin waa muruqyada ama murqaha, lallabbo, matag, shuban, iyo madax xanuun. Dhibaatooyinka ugu badan ee atorvastatin waa muruqyada ama murqaha, shuban, iyo kalagoys xanuun (arthralgia). Labada pravastatin iyo atorvastatin labaduba waxay sababi karaan waxyeelo kale sida dheefshiidka, dawakhaad, daal, firiiric, iyo infekshinka kaadi mareenka.
Halis ah waxyeelada daawooyinka stininka waxaa ka mid ah cudurka muruqyada (myopathy) iyo burburka degdega ah ee unugyada muruqyada (rhabdomyolysis). La xiriir bixiye daryeel caafimaad isla markiiba haddii aad isku aragto xanuun muruqa oo joogto ah ama aan la garanayn, daciifnimo, ama danqasho.
Pravastatin iyo atorvastatin sidoo kale waxay sababi karaan enzymes-ka beerka oo sareeya. Heerarka enzyme Liver waxay u baahan karaan in la hubiyo ka hor lana kormeero inta daaweynta socoto.
| Pravastatin | Khasaaraha | |||
| Waxyeellada | Ma khuseysaa? | Joogtaynta | Ma khuseysaa? | Joogtaynta |
| Xanuunka muruqyada | Haa | 10% | Haa | 4% |
| Lalabbo / matagid | Haa | 7% | Haa | 4% |
| Shuban | Haa | 7% | Haa | 7% |
| Dheef-shiidka | Haa | 3% | Haa | 5% |
| Dawakhaad | Haa | 4% | Haa | * |
| Madax xanuun | Haa | 6% | Maaha | - |
| Daal | Haa | 3% | Haa | * |
| Firiiric | Haa | 5% | Haa | * |
| Arthralgia | Haa | * | Haa | 7% |
| Caabuqa kaadi mareenka | Haa | 3% | Haa | 6% |
Joogtayntu kuma salaysna xogta laga soo qaaday tijaabo madax-ilaa-madax ah. Tani ma noqon karto liistada dhameystiran ee waxyeelooyinka xun ee dhici kara. Fadlan tixraac dhakhtarkaaga ama daryeel caafimaad si aad wax badan uga ogaato.
Xigasho: DailyMed ( Pravastatin ),, DailyMed ( Khasaaraha )
* lama soo sheegin
Isdhexgalka daroogada ee pravastatin iyo Lipitor
Pravastatin iyo atorvastatin waxay la falgalaan daawooyin la mid ah. Si kastaba ha noqotee, maadaama atorvastatin ay ugu horreyn dheef-shiid kiimikaadkiisu yahay 'CYP3A4 enzyme' ee beerka, waxay la macaamili kartaa daawooyin badan oo saameeya enzymes-ka 'CYP3A4' ee ku jira beerka.
Qaadashada daawooyinka sida cyclosporine, clarithromycin, ama ritonavir oo leh pravastatin ama atorvastatin waxay u horseedi kartaa heerar sare oo dhiigga ku jira dhiigga, taas oo kordhin karta halista waxyeellooyinka xun.
Antacids waxay faragalin ku yeelan kartaa dhuuqista daawooyinka 'statin' waxayna yareyneysaa waxtarkooda. Maamulka antacids iyo statins waa in lagu kala maqnaadaa ugu yaraan laba saacadood. Cholestyramine sidoo kale waxay yareyn kartaa nuugista iyo waxtarka statins. Maamulka cholestyramine iyo statins waa in lagu kala saaraa afar saacadood.
Niacin iyo fibrates waxay kordhin karaan halista myopathy iyo rhabdomyolysis marka lala qaato pravastatin ama atorvastatin.
Isticmaalka atorvastatin waa in laga fogaadaa ama lala socdo inta wax la cunayo casiir canab ah . Casiirka canabku wuxuu u dhaqmaa sida CYP3A4 inhibitor oo u horseedi kara heerar koror ah atorvastatin ee dhiigga wuxuuna kordhiyaa halista waxyeellooyinka.
| Daroogada | Fasalka daroogada | Pravastatin | Khasaaraha |
| Cyclosporine | Immunosuppressants | Haa | Haa |
| Clarithromycin Erythromycin | Antibiyootikada | Haa | Haa |
| Ketoconazole Itraconazole Voriconazole Posaconazole | Antifungals | Maaha | Haa |
| Ritonavir Simeprevir Ledipasvir Boceprevir Darunavir | Ka hortaga fayraska | Haa | Haa |
| Niacin | Wakiilada kahortaga | Haa | Haa |
| Fenofibrate Gemfibrozil | Fibrates | Haa | Haa |
| Digoxin | Glycosides wadnaha | Haa | Haa |
| Cholestyramine | Isku xigxigayaasha Bile acid | Haa | Haa |
| Aluminium hydroxide Hydroxide magnesium | Dawooyinka lidka ku ah | Haa | Haa |
Kala tasho xirfadle daryeel caafimaad isdhexgalka kale ee dawooyinka ee suurtogalka ah.
Digniinta pravastatin iyo Dibnaha
Pravastatin iyo atorvastatin waa in laga fogaadaa kuwa qaba cudurka beerka ee firfircoon ama heerarka enzyme sare ee beerka. Daawooyinka Statin waxay u horseedi karaan waxyeelo dheeri ah beerka qof qaba cudurka beerka.
Pravastatin iyo atorvastatin waa in aan loo isticmaalin kuwa leh taariikhda falcelinta xasaasiyadeed ee daawooyinka statin. Calaamadaha iyo astaamaha fal-celinta xasaasiga ah waxaa ka mid ah finan, cuncun, barar, iyo dhibaato neefsashada ah.
Daawooyinka Statin waxay qaadaan halista dhaawac murqo oo daran iyo murqo xanuun. Waxaa jiri kara halista sii kordheysa ee xanuunka murqaha kuwa ka weyn 65 sano ama kuwa leh xakameyn hypothyroidism ama dhibaatooyinka kelyaha.
Pravastatin iyo atorvastatin waa in aan loo isticmaalin kuwa uurka leh ama nuujinaya.
La hadal bixiye daryeel caafimaad si aad ugala hadasho digniinaha kale ee suurtagalka ah ama taxaddarka la xiriira pravastatin ama atorvastatin.
Su'aalaha badanaa la isweydiiyo ee ku saabsan pravastatin iyo Lipitor
Waa maxay pravastatin?
Pravastatin waa daawo guud oo loo isticmaalo in lagu yareeyo kolestaroolka lagana hortago dhibaatooyinka ka dhasha heerarka kolestaroolka sareeya. Magaca sumcadda pravastatin waa Pravachol. Waxaa loo qoondeeyay in la qaato hal mar maalintii fiidkii. Pravastatin waxaa loo heli karaa kiniin afka ah.
Waa maxay Qasaarahu?
Lipitor waa daawo magac ku caan ah oo ay soo saartay shirkadda Pfizer. Magaca guud ee Lipitor waa atorvastatin. Waxaa loo isticmaalaa in lagu daaweeyo heerarka kolestaroolka sareeya isla markaana yareeyo halista wadno qabadka iyo istaroogga. Qasaare ayaa loo qoray in la qaato hal mar maalintii subaxdii ama fiidkii. Waxaa loo heli karaa kiniin ahaan afka laga qaato.
Pravastatin iyo Lipitor isku mid ma yihiin?
Labada pravastatin iyo atorvastatin labaduba waa daawooyin loo isticmaalo in lagu yareeyo heerarka sare ee kolestaroolka. Si kastaba ha noqotee, iyagu isku mid ma aha. Atorvastatin waxaa ugu horreyn lagu dheef-saaraa nidaamka enzyme CYP P450 ee beerka halka pravastatin uu ku kala jaban yahay caloosha. Pravastatin sida caadiga ah waxaa la qaataa habeenki halka Lipitor la qaato subaxdii ama fiidkii.
Pravastatin ama Lipitor ma ka fiican yahay?
Labada pravastatin iyo Lipitor labaduba waa qaabab wax ku ool ah oo loo yaqaan 'statin therapy'. Labada daawoba waxay kaa caawin karaan kahortaga dhibaatooyinka heerarka kalastaroolka sareeya, sida atherosclerosis, wadna qabad, iyo istaroog. Qaar ka mid ah daraasadaha laga joornaalada wadnaha waxay ogaadeen in atorvastatin, maaddada firfircoon ee ku jirta Lipitor, ay ka waxtar badan tahay dawooyinka kale ee statin ee looga hortago dhacdooyinka wadnaha iyo xididdada wadnaha iyo istaroogga. Bixiye daryeel caafimaad ayaa ku siin kara talo caafimaad oo ku saabsan daawada ugu wanaagsan ee dawada.
Ma isticmaali karaa pravastatin ama Lipitor intaan uurka leeyahay?
Pravastatin iyo atorvastatin laguma talinayo in la qaato inta ay uurka leeyihiin. Labada daawoba waxay leeyihiin khatar sare oo ah inay keenaan cilado dhalasho. La tasho bixiye daryeel caafimaad si aad u hesho hagitaan ku saabsan daaweynta ugu fiican ee kolestaroolka sareeya inta aad uurka leedahay.
Ma ku isticmaali karaa pravastatin ama Lipitor khamri?
Ma jirto khatar caafimaad oo weyn oo ku lug leh cabitaanka qamriga dhexdhexaadka ah iyo statins. Daroogooyinka Statin iyo isticmaalka khamriga ee xad dhaafka ah dhaawici karaa beerka . La hadal bixiye daryeel caafimaad si aad u qiimeyso inay ammaan kuu tahay inaad cabto aalkolo inta aad qaadanaysid dawada 'statin'.
